Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.


Murine Hox genes are organized into four clusters that share many features with the homeotic clusters of Drosophila. This evolutionary conservation and the clear relationships between the position of a gene within a cluster and its expression pattern have led to the suggestion that the structure of the cluster is essential for proper regulation. Using a Hox… (More)