Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (anencephaly).

@article{Golden1995MultipleSO,
  title={Multiple sites of anterior neural tube closure in humans: evidence from anterior neural tube defects (anencephaly).},
  author={Jeffrey Alan Golden and G F Chernoff},
  journal={Pediatrics},
  year={1995},
  volume={95 4},
  pages={506-10}
}
OBJECTIVE Anterior neural tube closure in humans is thought to occur via a continuous process, culminating in the closure of the anterior neuropore. Recent studies have demonstrated that, in some species, the process is discontinuous, with four separate sites of closure initiation. In this study, we tested the hypothesis that humans, like mice and other experimental animals, have multiple sites of anterior neural tube closure. METHODS Twenty human fetuses and neonates with open anterior… CONTINUE READING

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