Multiple signals regulate axon regeneration through the nogo receptor complex

@article{Yamashita2005MultipleSR,
  title={Multiple signals regulate axon regeneration through the nogo receptor complex},
  author={Toshihide Yamashita and Masashi Fujitani and Satoru Yamagishi and Katsuhiko Hata and Fumiaki Mimura},
  journal={Molecular Neurobiology},
  year={2005},
  volume={32},
  pages={105-111}
}
Several myelin-derived proteins have been identified as components of central nervous system (CNS) myelin, which prevents axonal regeneration in the adult vertebrate CNS. The discovery of the receptor for these proteins was a major step toward understanding the failure of axon regeneration. The receptor complex consists of at least three elements: the p75 receptor (p75NTR), the Nogo receptor and LINGO-1. Downstream from the receptor complex, RhoA activation has been shown to be a key element of… CONTINUE READING

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