Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1

@article{Sacchetti2006MultipleSP,
  title={Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1},
  author={Paola Sacchetti and Rodolphe Carpentier and Pascaline S{\'e}gard and C{\'e}cile Oliv{\'e}-Cren and Philippe Lefebvre},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={5515 - 5527}
}
The orphan nuclear receptor nurr1 (NR4A2) is an essential transcription factor for the acquisition and maintenance of the phenotype of dopamine (DA)-synthesizing neurons in the mesencephalon. Although structurally related to ligand-regulated nuclear receptors, nurr1 is functionally atypical due to its inability to bind a cognate ligand and to activate transcription following canonical nuclear receptor (NR) rules. Importantly, the physiological stimuli that activate this NR and the signaling… CONTINUE READING
24 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…