Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance.

@article{Webber2005MultipleSP,
  title={Multiple signaling pathways regulate FGF-2-induced retinal ganglion cell neurite extension and growth cone guidance.},
  author={Christine A. Webber and Yuan Yuan Chen and Carrie Lynn Hehr and James D. Johnston and Rami Halabi},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={30 1},
  pages={37-47}
}
Growth cones use cues in their environment in order to grow in a directed fashion to their targets. In Xenopus laevis, fibroblast growth factors (FGFs) participate in retinal ganglion cell (RGC) axon guidance in vivo and in vitro. The main intracellular signaling cascades known to act downstream of the FGF receptor include the mitogen-activated protein kinase (MAPK), phospholipase Cgamma (PLCgamma) and phosphotidylinositol 3-kinase (PI3K) pathways. We used pharmacological inhibitors to identify… CONTINUE READING

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