Multiple signaling pathways leading to the activation of interferon regulatory factor 3.

@article{Servant2002MultipleSP,
  title={Multiple signaling pathways leading to the activation of interferon regulatory factor 3.},
  author={Marc J. Servant and Nathalie Grandvaux and John Hiscott},
  journal={Biochemical pharmacology},
  year={2002},
  volume={64 5-6},
  pages={985-92}
}
Virus infection of susceptible cells activates multiple signaling pathways that orchestrate the activation of genes, such as cytokines, involved in the antiviral and innate immune response. Among the kinases induced are the mitogen-activated protein (MAP) kinases, Jun-amino terminal kinases (JNK) and p38, the IkappaB kinase (IKK) and DNA-PK. In addition, virus infection also activates an uncharacterized VAK responsible for the C-terminal phosphorylation and subsequent activation of interferon… CONTINUE READING

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