Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression.

@article{Dore2009MultipleSP,
  title={Multiple signaling pathways converge to regulate bone-morphogenetic-protein-dependent glial gene expression.},
  author={Justin J Dore and John C Dewitt and Nithya G Setty and Mareshia D Donald and Esther Joo and Melissa A. Chesarone and Susan J. Birren},
  journal={Developmental neuroscience},
  year={2009},
  volume={31 6},
  pages={473-86}
}
A fundamental problem in developmental neuroscience is understanding how extracellular cues link to complex intracellular signaling pathways to drive stage-specific developmental decisions. During the formation of the mammalian peripheral nervous system, bone morphogenetic proteins (BMPs) promote neuronal differentiation. BMPs also maintain the expression of early glial genes such as GFAP, while blocking the acquisition of a mature, myelinating Schwann cell phenotype. We investigated the BMP… CONTINUE READING
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