Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation.

@article{Franceschi2003MultipleSP,
  title={Multiple signaling pathways converge on the Cbfa1/Runx2 transcription factor to regulate osteoblast differentiation.},
  author={Renny T. Franceschi and Guozhi Xiao and Di Jiang and Rajaram Gopalakrishnan and Shuying Yang and Elizabeth Reith},
  journal={Connective tissue research},
  year={2003},
  volume={44 Suppl 1},
  pages={109-16}
}
The Cbfa1/Runx2 transcription factor is essential for osteoblast differentiation. However, levels of Runx2 are often not well correlated with its transcriptional activity suggesting that this factor must be activated either by covalent modification or through interactions with other nuclear components. Runx2 is phosphorylated and activated by the mitogen-activated protein kinase (MAPK) pathway. This pathway is stimulated in at least two ways: by binding of type I collagen to alpha2beta1… CONTINUE READING