Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.

@article{Tamagno2003MultipleSE,
  title={Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.},
  author={Elena Tamagno and Maurizio Parola and Michela Guglielmotto and Gianni Santoro and Paola Bardini and Laura Marra and Massimo Tabaton and Oliviero Danni},
  journal={Free radical biology & medicine},
  year={2003},
  volume={35 1},
  pages={45-58}
}
Current evidence suggests that amyloid beta peptides (Abeta) may play a major role in the pathogenesis of Alzheimer's disease by eliciting oxidative stress and neuronal apoptosis. In this study we have used differentiated SK-N-BE neurons to investigate molecular mechanisms and regulatory pathways underlying apoptotic neuronal cell death elicited by Abeta(1-40) and Abeta(1-42) peptides as well as the relationships between apoptosis and oxidative stress. Abeta peptides, used at concentrations… CONTINUE READING