Multiple serotonin receptors: regional distribution and effect of Raphe lesions.

@article{Blackshear1981MultipleSR,
  title={Multiple serotonin receptors: regional distribution and effect of Raphe lesions.},
  author={M. A. Blackshear and L. Steranka and E. sanders-Bush},
  journal={European journal of pharmacology},
  year={1981},
  volume={76 4},
  pages={
          325-34
        }
}
  • M. A. Blackshear, L. Steranka, E. sanders-Bush
  • Published 1981
  • Chemistry, Medicine
  • European journal of pharmacology
    • These studies confirm and extend the recent work suggesting that [3H]lysergic acid diethylamide (LSD) labels two distinct binding sites in rat brain resembling serotonin (5HT) receptors. Although Scatchard analyses of [3H]LSD binding to membranes prepared from cortex/hippocampus were linear, the heterogeneity of the [3H]LSD binding sites was clearly demonstrated in displacement studies. The displacement curves for both 5HT and spiperone were bisigmoidal with the concentration required to… CONTINUE READING
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    102 Citations
    Background Citations
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    Methods Citations
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    102 Citations
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    References

    SHOWING 1-10 OF 21 REFERENCES
    Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.
    • 479
    Serotonin receptors in hippocampus and frontal cortex.
    • 87
    Stereospecific binding ofd-lysergic acid diethylamide (LSD) to brain membranes: Relationship to serotonin receptors
    • 160
    • PDF
    Selective labeling of serotonin receptors by d-[3H]lysergic acid diethylamide in calf caudate.
    • P. Whitaker, P. Seeman
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1978
    • 34
    • PDF
    Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat.
    • 332
    Serotonergic component of neuroleptic receptors
    • 621
    Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain
    • 175
    Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.
    • 1,333
    High-affinity binding of (3H) 5-hydroxytryptamine to brain synaptosomal membranes: comparison with (3H) lysergic acid diethylamide binding.
    • 111
    Behavioral evidence for supersensitivity following destruction of central serotonergic nerve terminals by 5,7-dihydroxytryptamine.
    • 185