Multiple serotonin receptors: regional distribution and effect of Raphe lesions.

  title={Multiple serotonin receptors: regional distribution and effect of Raphe lesions.},
  author={M. A. Blackshear and L. Steranka and E. sanders-Bush},
  journal={European journal of pharmacology},
  volume={76 4},
  • M. A. Blackshear, L. Steranka, E. sanders-Bush
  • Published 1981
  • Chemistry, Medicine
  • European journal of pharmacology
  • These studies confirm and extend the recent work suggesting that [3H]lysergic acid diethylamide (LSD) labels two distinct binding sites in rat brain resembling serotonin (5HT) receptors. Although Scatchard analyses of [3H]LSD binding to membranes prepared from cortex/hippocampus were linear, the heterogeneity of the [3H]LSD binding sites was clearly demonstrated in displacement studies. The displacement curves for both 5HT and spiperone were bisigmoidal with the concentration required to… CONTINUE READING
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