Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4.

@article{Isin2007MultipleSS,
  title={Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4.},
  author={Emre Mehmet Isin and F Peter Guengerich},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 9},
  pages={6863-74}
}
Cytochrome P450 (P450) 3A4 is an extensively studied human enzyme involved in the metabolism of >50% of drugs. The mechanism of the observed homotropic and heterotropic cooperativity in P450 3A4-catalyzed oxidations is not well understood, and together with the cooperative behavior, a detailed understanding of interaction of drug inhibitors with P450 3A4 is important in predicting clinical drug-drug interactions. The interactions of P450 3A4 with several structurally diverse inhibitors were… CONTINUE READING

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