Multiple sequence alignment with user-defined anchor points

@article{Morgenstern2006MultipleSA,
  title={Multiple sequence alignment with user-defined anchor points},
  author={Burkhard Morgenstern and Sonja J. Prohaska and Dirk P{\"o}hler and Peter F. Stadler},
  journal={Algorithms for Molecular Biology},
  year={2006},
  volume={1},
  pages={6 - 6}
}
Automated software tools for multiple alignment often fail to produce biologically meaningful results. In such situations, expert knowledge can help to improve the quality of alignments. Herein, we describe a semi-automatic version of the alignment program DIALIGN that can take pre-defined constraints into account. It is possible for the user to specify parts of the sequences that are assumed to be homologous and should therefore be aligned to each other. Our software program can use these… CONTINUE READING
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