Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein-linked receptors.

@article{Attwood1991MultipleSA,
  title={Multiple sequence alignment of protein families showing low sequence homology: a methodological approach using database pattern-matching discriminators for G-protein-linked receptors.},
  author={Teresa K. Attwood and E. E. Eliopoulos and John B. C. Findlay},
  journal={Gene},
  year={1991},
  volume={98 2},
  pages={153-9}
}
A multiple alignment has been constructed, containing 37 sequences from related families of membrane-bound receptors believed to share the same structural framework as rhodopsin. Sequence homology within families was high (occasionally greater than 90%), but homology between them was generally low (20% or less). Database pattern-scanning methods were therefore used to construct a set of discriminators to aid both the task of alignment and the identification of distantly related sequences… CONTINUE READING