Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry

@article{Goudie1993MultipleSS,
  title={Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry},
  author={David R. Goudie and Martin A.R. Yuille and Margaret A. Leversha and R. A. Furlong and Nigel P. Carter and Michael J. Lush and N. A. Affara and M. A. Ferguson-Smith},
  journal={Nature Genetics},
  year={1993},
  volume={3},
  pages={165-169}
}
A gene (ESS 1) predisposing to the development of multiple invasive but self–healing skin tumours (squamous cell epitheliomata) is tightly linked to the polymorphic DNA marker D9S53 (9q31) with a maximum lod score of 9.02 at a recombination fraction of 0.03. Multipoint linkage analysis demonstrates that the disease locus is most likely to lie between D9S58 (9q22.3–31) and ASSP3 (9q11–q22). Comparison of markers associated with ESS1 in independently ascertained families suggests a common origin… CONTINUE READING

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