Multiple sclerosis.

@article{Hafler2004MultipleS,
  title={Multiple sclerosis.},
  author={David A. Hafler},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 6},
  pages={788-94}
}
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new… CONTINUE READING
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