Multiple sclerosis is primarily a neurodegenerative disease

@article{Chaudhuri2013MultipleSI,
  title={Multiple sclerosis is primarily a neurodegenerative disease},
  author={Abhijit Chaudhuri},
  journal={Journal of Neural Transmission},
  year={2013},
  volume={120},
  pages={1463-1466}
}
  • A. Chaudhuri
  • Published 28 August 2013
  • Medicine
  • Journal of Neural Transmission
The precise pathogenesis of multiple sclerosis is unknown. The assumption of a primary immunopathogenesis of the disease is seriously flawed and has failed to deliver an effective therapy for most patients. The progressive degeneration of grey and white matter is integral to the natural history of the disease and is reflected in the atrophy of brain and spinal cord. Demyelination is an essential component of this primary neurodegenerative process rather than the target of a systemic immune… 
Novel Therapeutic Approaches to Multiple Sclerosis: Neuroprotective Drugs for Relapsing-Remitting Multiple Sclerosis
TLDR
This review focuses on promising neuroprotective or neuroregenerative drugs that are currently approved or in clinical trials that provide new valid alternatives that significantly could impact on disease progression and neurodegenerative changes in MS.
Pathogenesis of autoimmune demyelination: from multiple sclerosis to neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody‐associated disease
TLDR
A review of multiple sclerosis, neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody‐associated disease, which aims to synthesise the clinical characteristics and pathological findings, discuss existing and emerging hypotheses regarding the aetiology of demyelination and evaluate recent pathogenicity studies involving T cells, B cells, and autoantibodies and their implications in human demYelination.
Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
TLDR
This Narrative Review focuses on alternative techniques with the potential of detecting neurodegenerative events in the brain of subjects with MS prior to the atrophic stage, and recent findings provide the promising prospect of demonstrating degenerative brain pathology in patients with MS before atrophy has installed.
Cooccurrence of Multiple Sclerosis and Idiopathic Basal Ganglia Calcification
TLDR
A cooccurrence of idiopathic basal ganglia calcification with multiple sclerosis is described, which is a very rare event.
Differential contribution of microglia and monocytes in neurodegenerative diseases
TLDR
This review will summarize and discuss the current knowledge of the differential contributions of microglia and monocytes in the common neurodegenerative diseases AD, PD, and ALS, as well as multiple sclerosis, which is now regarded as a combination of inflammatory processes and Neurodegeneration.
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality. It has been shown that neuroinflammation precedes
Relationship between Mitochondrial Dysfunction and Multiple Sclerosis: A Review Study
TLDR
The evidence has shown mitochondrial dysfunction plays an important role in axonal degeneration in all stages of MS due to neuronal cell loss and activation pro-inflammatory cytokines, which increases inflammation and demyelination in neurons.
Characterisation of the transcriptomic and proteomic profile of astrocytes in multiple sclerosis
TLDR
Investigation of the transcriptomic and proteomic profile of astrocytes in MS NAWM to determine whether specific astroglial changes exist, which may contribute/prevent disease progression in MS indicates that further investigations into the protective roles of astroskeletal changes in regulating iron and oxidative stress in MSNAWM are warranted.
Multifaceted Role of Matrix Metalloproteinases in Neurodegenerative Diseases: Pathophysiological and Therapeutic Perspectives
TLDR
The current review delineates the several emerging evidence demonstrating the effects of MMPs in the progression of NDs, wherein they regulate several processes, such as (neuro)inflammation, microglial activation, amyloid peptide degradation, blood brain barrier disruption, dopaminergic apoptosis, and α-synuclein modulation, leading to neurotoxicity and neuron death.
Cladribine tablets’ potential role as a key example of selective immune reconstitution therapy in multiple sclerosis
  • A. Boyko, O. Boyko
  • Medicine
    Degenerative neurological and neuromuscular disease
  • 2018
TLDR
Clinical benefits of cladribine tablets in these studies include decreased relapse rate and disability progression with large reductions in lesion activity, and protection against brain volume loss, which clearly point to an interesting area of research.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 11 REFERENCES
Multiple sclerosis: an immune or neurodegenerative disorder?
TLDR
Data that support neurodegeneration as the major cause of irreversible neurological disability in MS patients are reviewed and it is questioned whether inflammatory demyelination is primary or secondary in the disease process.
Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
TLDR
Clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis, who died during or shortly after the onset of a relapse, raise the possibility of some novel process underlying new lesion formation in multiple sclerosis.
Amyotrophic lateral sclerosis is not linked to multiple sclerosis in a population based study
TLDR
In a large prospective, population based ALS study in the Netherlands, all patients with ALS and MS were identified and screened them for repeat expansions in the C9ORF72 gene, which is a major ALS gene and could perhaps also play a role in MS pathogenesis.
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study
Multiple sclerosis is not an autoimmune disease.
TLDR
The evolution of the plaques in patients with MS as seen in MR spectroscopyisdifferent from ADEM and the most extensivechanges seen at the center of the plaque paralleling the decrease in the magnetization transfer ratio are seen.
Multiple sclerosis and amyotrophic lateral sclerosis: is there a link?
TLDR
Relatives of MS patients were significantly more prone to ALS and vice versa, and this could give clues about the common features that the two disease share.
Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey.
TLDR
It is concluded that autoimmune disease is more common in first-degree relatives of patients with multiple sclerosis and hypothesize that common genetic susceptibility factors for autoimmunity co-exist with additional disease specific genetic or environmental factors, which determine clinical phenotype in the individual.
Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis.
TLDR
Exposure to interferon beta was not associated with a statistically significant difference in the hazard of reaching an EDSS score of 6 when either the contemporary control cohort or the historical control cohort was considered, and propensity score adjustment did not substantially change the results.
Ultrastructure of multiple sclerosis.
TLDR
It is concluded that disturbance of the myelinating function of oligodendrocytes may be a critical event in the pathogenesis of multiple sclerosis.
Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72
TLDR
It is proposed that MS-associated neuroinflammation may affect penetrance and progression of the C9ORF72 expansion, and Aberrant downregulation of CXCL10 may explain the predisposition of C9ORN72 expansion carriers to develop ALS in the context of MS.
...
1
2
...