Psoriasis during interferon beta treatment for multiple sclerosis
Among 51 patients with clinically probable multiple sclerosis three had typical chronic psoriasis. The incidence of psoriasis in the studies group of multiple sclerosis patients was higher (one case per 17 patients) than in the general population (one per 33 subjects). In all three cases psoriasis developed before the beginning of remitting multiple sclerosis and showed no correlation with the exacerbations of the neurological disease or with the degree of neurological function loss. The presence of histocompatibility antigens (HLA), immunopathological and biochemical changes in both diseases is discussed.