Multiple sclerosis and central nervous system demyelination.

  title={Multiple sclerosis and central nervous system demyelination.},
  author={Sandrine Pouly and Jack P. Antel},
  journal={Journal of autoimmunity},
  volume={13 3},
Multiple sclerosis (MS) is characterized by multifocal areas within the CNS of demyelination with relative but not absolute axonal sparing. Initial lesion development appears dependent on T cell infiltration into the CNS; however, lesion expansion may reflect tissue injury induced by additional effector mechanisms derived from cells of the immune system and endogenous CNS cells (glial cells). This relative susceptibility to injury in MS of myelin and its cell of origin, the oligodendrocyte (OL… CONTINUE READING