Multiple sclerosis

@article{Walther1999MultipleS,
  title={Multiple sclerosis},
  author={Ernst U. Walther and Reinhard Hohlfeld},
  journal={Neurology},
  year={1999},
  volume={53},
  pages={1622 - 1622}
}
Article abstract Interferon beta (IFNβ) reduces the relapse rate, disease activity as measured by serial MRI scanning, and disease progression of MS. Therapy with IFNβ may be associated with a number of adverse reactions. Relatively frequent side effects include flu-like symptoms, transient laboratory abnormalities, menstrual disorders, and increased spasticity. Dermal injection site reactions occur after subcutaneous application of IFNβ-1b and IFNβ-1a. Possible side effects of IFNβ include… 
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244 Citations

Arthritis during interferon beta-1b treatment in multiple sclerosis

TLDR
Clinical and laboratory findings of two MS patients who developed arthritis during IFN-β1b treatment, probably of autoimmune origin are presented.

Interferon-beta injection site reactions in patients with multiple sclerosis

TLDR
Injection site reactions (ISRs), featured by erythema, edema, pain, and pruritus, are the most common adverse reactions and it is very important to adopt strategies to minimize ISRs by proper patient education and counseling.

The safety and efficacy of IFN-β products for the treatment of multiple sclerosis

TLDR
Overall, IFN-β is safe and generally well tolerated, and reported adverse events were comparable between preparations, and systemic side effects can be effectively managed by dose escalation, use of an auto-injector and careful clinical monitoring.

Review of interferon beta-1b in the treatment of early and relapsing multiple sclerosis

TLDR
There is growing evidence from clinical trials on relapsing-remitting MS and clinically isolated syndromes suggestive of MS that IFNβ-1b reduces the frequency and severity of relapses and the development of new and active brain lesions as assessed by magnetic resonance imaging.

Cutaneous Adverse Events Associated with Interferon-β Treatment of Multiple Sclerosis

TLDR
A multiple sclerosis patient treated with interferon-β who developed new-onset psoriasis is presented and it is suggested that skin lesions may serve as biomarkers to allocate MS patients to adequate disease-modifying drugs.

Managing Risks with Immune Therapies in Multiple Sclerosis

TLDR
This paper aims to provide an overview of currently available MS therapies, their modes of action and safety profiles, and the necessary therapy monitoring.

Thrombotic microangiopathy associated with use of interferon-beta

TLDR
A patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy is reported.

Current Clinical Applications of Interferon

TLDR
Flu-like symptoms, fever, headache, fatigue and myalgia are experienced by three quarters of patients, but this reaction can usually be managed with NSAIDs and resolved within the first three months after initiation of IFN--1b treatment.

Psoriasis during interferon beta treatment for multiple sclerosis

TLDR
This case further supports that activation of psoriasis might be a rare side effect of IFNB therapy and suggests careful evaluation of concomitant morbidity to allow a patient-oriented treatment strategy.

Interferons in multiple sclerosis.

  • L. Kappos
  • Medicine, Biology
    Neurologic clinics
  • 2005
...

References

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TLDR
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TLDR
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Autoimmune events during interferon beta-1b treatment for multiple sclerosis

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  • 1999
TLDR
The case of a 35 year old man with multiple sclerosis who became allergic to intravenous methyl prednisolone after the initiation of treatment with interferon β-1b is presented and what part the drug could have played in this is discussed.

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TLDR
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