Multiple sclerosis

@article{Compston2008MultipleS,
  title={Multiple sclerosis},
  author={Alastair Compston and Alasdair J. Coles},
  journal={The Lancet},
  year={2008},
  volume={372},
  pages={1502-1517}
}
Multiple sclerosis is primarily an inflammatory disorder of the brain and spinal cord in which focal lymphocytic infiltration leads to damage of myelin and axons. Initially, inflammation is transient and remyelination occurs but is not durable. Hence, the early course of disease is characterised by episodes of neurological dysfunction that usually recover. However, over time the pathological changes become dominated by widespread microglial activation associated with extensive and chronic… Expand

Paper Mentions

Interventional Clinical Trial
This study wants to investigate whether exercise booster sessions applied in the follow-up period after an exercise intervention can increase the sustainability of exercise induced… Expand
ConditionsMultiple Sclerosis
InterventionCombination Product
Interventional Clinical Trial
This study seeks to investigate whether early exercise efforts can expand the use of exercise in Multiple sclerosis (MS), from symptom treatment only, to early supplementary… Expand
ConditionsMultiple Sclerosis
InterventionBehavioral, Combination Product
Interventional Clinical Trial
Multiple sclerosis (MS) is a disease that causes damage within the central nervous system and results in deficits of body functions. The investigators propose a pilot randomized… Expand
ConditionsMultiple Sclerosis
InterventionOther
Observational Patient Registry Clinical Trial
Patients with Multiple Sclerosis (MS) have reduced functional capacity due to clinical symptoms of the disease, resulting in decreased participation in daily living activities and… Expand
ConditionsMultiple Sclerosis
InterventionOther
MAGNETIC RESONANCE SPECTROSCOPY OF NORMAL APPEARING WHITE MATTER IN EARLY RELAPSING-REMITTING MULTIPLE SCLEROSIS Enas
Back ground: Multiple sclerosis (MS) is an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged .MS is a chronic disease of the central nervousExpand
Progress in understanding the pathophysiology of multiple sclerosis.
TLDR
Recent pathological and imaging findings have prompted reconsideration of the clinical phenotypes of MS patients proposed by Lublin's 2013 classification, including clinical and MRI signs of activity, and new imaging biomarkers of remyelination are now being investigated for new strategies of MS management. Expand
Neuroimaging Techniques to Assess Inflammation in Multiple Sclerosis
TLDR
The scope of this review is to examine the various neuroimaging techniques and those biophysical quantities that can be non-invasively detected to enlighten the different aspects of neuroinflammation. Expand
Modelling Multiple Sclerosis In Vitro and the Influence of Activated Macrophages
TLDR
This chapter will focus on MS pathology and the models that exist for investigating this disease, especially zooming in on in vitro models. Expand
Detecting neurodegenerative pathology in multiple sclerosis before irreversible brain tissue loss sets in
TLDR
This Narrative Review focuses on alternative techniques with the potential of detecting neurodegenerative events in the brain of subjects with MS prior to the atrophic stage, and recent findings provide the promising prospect of demonstrating degenerative brain pathology in patients with MS before atrophy has installed. Expand
Quantifying multiple sclerosis pathology in post mortem spinal cord using MRI
TLDR
Combining advanced quantification of histological features with quantitative - particularly diffusion-based - MRI techniques provide a new platform for high-quality MR/pathology data generation and to more accurately quantify grey matter pathology in the MS spinal cord. Expand
Multivariate fuzzy analysis of brain tissue volumes and relaxation rates for supporting the diagnosis of relapsing-remitting multiple sclerosis
TLDR
This work proposes an innovative system, employing a multivariate analysis approach, of mining and integrating multiple sensitive neuroimaging markers, including but not limited to the WM lesion load, into classification models for supporting a more robust diagnosis of Relapsing-Remitting-MS (RR-MS) already at an initial clinical event. Expand
The early diagnosis and treatments in multiple sclerosis
TLDR
A review looks at MS diagnostic criteria newly published in 2016 and highlights the importance of differential diagnosis and early treatment. Expand
Pregnancy-Related Immune Changes and Demyelinating Diseases of the Central Nervous System
TLDR
Current knowledge on the immune status during pregnancy is summarized, the relationship between pregnancy-related immune changes and demyelinating diseases of the central nervous system is discussed, and the immune response of patients with autoimmune disease complicated with pregnancy is different. Expand
Multiple sclerosis: clinical aspects
TLDR
The epidemiology, diagnosis, disease course, and prognosis of multiple sclerosis is discussed and a combination of clinical, imaging, and laboratory markers can be useful in predicting clinical course and optimizing treatment in individual patients. Expand
...
1
2
3
4
5
...