Multiple sclerosis

@article{Compston2002MultipleS,
  title={Multiple sclerosis},
  author={Alastair Compston and Alasdair J. Coles},
  journal={The Lancet},
  year={2002},
  volume={359},
  pages={1221-1231}
}
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162 Citations

162 Citations

Citation Type

Citation Type

The nature of genetic and environmental susceptibility to multiple sclerosis
TLDR
It is demonstrated that genetic-susceptibility is confined to less than 7.3% of populations throughout Europe and North America, and more than 92.7% of individuals in these populations have no chance whatsoever of developing MS, regardless of their environmental experiences.
Genetics of Multiple Sclerosis
TLDR
The genome-wide association studies in MS in large populations in combination with expression quantitative loci (eQTL) and a better understanding of the functional elements in the human genome have promoted a deeper knowledge of MS genetics in the last 10 years, but the genetic implication in the disease is still far from understanding.
Conversion of clinically isolated syndrome to multiple sclerosis: a prospective study.
TLDR
A single-center prospective longitudinal study aimed at identification of the most powerful independent predictors for conversion from CIS to MS, utilizing the 2010 McDonald MS criteria and focusing on selected demographic, clinical, radiographical, cerebrospinal fluid, OCB and electrophysiological parameters.
SeXX Matters in Multiple Sclerosis
TLDR
Current knowledge on the sexual dimorphism in MS is outlined and the interplay of sex chromosomes, sex hormones, and the immune system in driving MS disease susceptibility and progression is discussed.
The epigenetics of multiple sclerosis
Differential white and gray matter damage in highly active multiple sclerosis: A prospective cohort study
Multiple sclerosis
TLDR
This Primer provides an overview of the immunopathology, diagnosis and management of multiple sclerosis, characterized by the formation of demyelination lesions throughout the central nervous system, leading to neurological dysfunction.
Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
TLDR
CSF-OCB presence is associated with higher risk of reaching EDSS milestones and conversion to SPMS, and higher disease modifying effect of OCB presence in the early inflammatory stages of MS is suggested.
Shared breastfeeding & other early multiple sclerosis risk factors: A case-control study.
Human Commensal Prevotella histicola Ameliorates Disease as Effectively as Interferon-Beta in the Experimental Autoimmune Encephalomyelitis
TLDR
It is indicated that the human gut commensal P. histicola can suppress disease as effectively as commonly used MS drug IFNβ and may provide an alternative treatment option for MS patients.
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References

SHOWING 1-10 OF 91 REFERENCES
The genetic epidemiology of multiple sclerosis
A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.
TLDR
The results thus provide further supporting evidence for the candidature of 6p, 17q, 19q and 1p as regions encoding susceptibililty genes for multiple sclerosis.
A meta-analysis of genomic screens in multiple sclerosis
  • 2001
We combined the raw genotyping data from three large multiple sclerosis genome screens and performed a global met-analysis in order to compare and summarize the linkage results from the different…
Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
TLDR
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
The natural history of multiple sclerosis: a geographically based study. 2. Predictive value of the early clinical course.
TLDR
The time to reach successive levels of disability defined by the Kurtzke Disability Status Scale in 1,099 MS patients followed at University Hospital, London, Canada between 1972 and 1984 is recorded.
A LONGITUDINAL STUDY OF ABNORMALITIES ON MRI AND DISABILITY FROM MULTIPLE SCLEROSIS
TLDR
In patients who first present with isolated syndromes suggestive of multiple sclerosis, the increases in the volume of the lesions seen on magnetic resonance imaging of the brain in the first five years correlate with the degree of long-term disability from multiple sclerosis.
Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.
TLDR
It is proposed that optic nerve damage in this disease could be immunologically mediated and that mitochondrial genes may contribute to susceptibility to MS.
The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
TLDR
The outcome of multiple sclerosis, assessed according to the Kurtzke Disability Status Scale, was reviewed in 1,099 consecutive patients followed in London, Canada, between 1972 and 1984 and the rate at which disability develops after the onset of a progressive phase of MS is presented.
Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.
TLDR
Examination of 86 brain specimens by PCR demonstrated that HHV-6 was present in > 70% of MS cases and controls and is thus a commensal virus of the human brain, suggesting an association of HHv-6 with the etiology or pathogenesis of MS.
The effect of interferon beta-1 b treatment on MRI measures of cerebral atrophy in secondary progressive multiple sclerosis
The recently completed European trial of interferon betahad a greater reduction of cerebral volume in the placebo group (mean reduction at month 36: placebo 5.1%, IFNβ1b (IFNβ-1b) in patients with…
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