Multiple sclerosis–associated retrovirus (MSRV) in Sardinian MS patients
@article{Dolei2002MultipleSR, title={Multiple sclerosis–associated retrovirus (MSRV) in Sardinian MS patients}, author={Antonina Dolei and Caterina Serra and Giuseppe Mameli and Maura Pugliatti and GianPietro Sechi and M C Cirotto and Giulio Rosati and Stefano Sotgiu}, journal={Neurology}, year={2002}, volume={58}, pages={471-473} }
Abstract—Blood and CSF of Sardinian patients with MS and neurologic control subjects were tested for MS-associated retrovirus (MSRV). CSF detection in MS was 50% at clinical onset, increasing with temporal disease progression, and 40% in control subjects. In blood, MSRV was detected in all MS patients, in most patients with inflammatory neurologic diseases, and rarely in healthy blood donors. MSRV may represent a marker of neurologic diseases of inflammatory origin.
103 Citations
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A MS-associated retrovirus in the CSF may have gliotoxic properties and could be associated with a more disabling MS, and this hypothesis was tested in untreated patients with MS.
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It is confirmed that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.
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- Medicine, BiologyMultiple sclerosis
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- Medicine, BiologyMultiple sclerosis
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- Biology, MedicineProceedings of the National Academy of Sciences
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- Biology, MedicineReviews in medical virology
- 2005
The hypothesis that human endogenous retroviruses play a role in autoimmune diseases is subject to increasing attention and they have been isolated from MS samples of plasma, serum and CSF, and characterised to some extent at the nucleotide, protein/enzyme, virion and immunogenic level.
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- Biology, MedicineJournal of NeuroVirology
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A parallel between the effects of these cytokines on MSRV production in vitro and on MS disease in vivo is observed, which deserves further elucidations.
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- Medicine, BiologyFrontiers in Immunology
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The role of infectious factors in Sardinian patients with MS is compared with the findings reported in other populations and a role in pathogenesis, prognosis, and prediction of treatment response has been proposed for HERV.
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- Biology, MedicineJournal of NeuroVirology
- 2011
It is suggested that there are no appreciable humoral or cellular immune responses against MSRV/HERV-W in patients with MS, and strategies other than measurement of immune responses will be required to further elucidate the relationship between MSRv/HERv-W and MS.
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