Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis.

@article{Bonetti1997MultipleSO,
  title={Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis.},
  author={Bruno Bonetti and Cedric S Raine},
  journal={Annals of neurology},
  year={1997},
  volume={42 1},
  pages={74-84}
}
To investigate whether apoptosis is involved in the fate of oligodendrocytes in chronic multiple sclerosis lesions, the pro-apoptotic molecules fas and tumor necrosis factor receptors and the anti-apoptotic molecule bcl-2 were examined by immunohistochemistry, and DNA fragmentation was assessed by an end labeling technique. Fas and both tumor necrosis factor receptors were preferentially expressed on oligodendrocytes in multiple sclerosis lesions, this phenotype being more evident at the lesion… CONTINUE READING