Multiple sclerosis: etiological mechanisms and future directions.

  title={Multiple sclerosis: etiological mechanisms and future directions.},
  author={John D Lutton and Ronald Winston and Toby C. Rodman},
  journal={Experimental biology and medicine},
  volume={229 1},
Multiple sclerosis (MS) is a complex human autoimmune-type disease with a predominantly unknown etiology. Immunologic destruction of myelin basic protein (MBP) throughout the nervous system is the major pathology of multiple sclerosis. This review will attempt to update new information about basic mechanisms and therapeutic management of the disease. The significance of the structure of MBP is discussed with respect to the contribution of such structures to the disease process. A number of MBP… CONTINUE READING


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  • WA Sheremuta, LD Blumhardt, Rice GPA, MA Libonati, CM Dalton, KA Miszkiel
  • N EngI J Med
  • 2003

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  • 2002

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