Multiple sclerosis: distribution of inflammatory cells in newly forming lesions.

Abstract

OBJECTIVE CD4 T-cell-dependent macrophage activation directed against a myelin or oligodendrocyte antigen is generally thought to be the mechanism causing myelin destruction in multiple sclerosis (MS). However, areas within expanding MS lesions may exhibit prominent oligodendrocyte loss and apoptosis in the absence of infiltrating lymphocytes. The present… (More)
DOI: 10.1002/ana.21800

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Cite this paper

@article{Henderson2009MultipleSD, title={Multiple sclerosis: distribution of inflammatory cells in newly forming lesions.}, author={Andrew D Henderson and Michael Barnett and John D. E. Parratt and John W. Prineas}, journal={Annals of neurology}, year={2009}, volume={66 6}, pages={739-53} }