Multiple sclerosis: death receptor expression and oligodendrocyte apoptosis in established lesions.

@article{Cannella2007MultipleSD,
  title={Multiple sclerosis: death receptor expression and oligodendrocyte apoptosis in established lesions.},
  author={Barbara A Cannella and Stefanie Gaupp and Kakuri M Omari and Cedric S Raine},
  journal={Journal of neuroimmunology},
  year={2007},
  volume={188 1-2},
  pages={128-37}
}
To determine whether TNF and TRAIL death receptors (DR), and decoy receptors (DcR), play a role in oligodendrocyte depletion in the lesions of chronic multiple sclerosis (MS), we investigated the presence and functionality of these molecules on oligodendrocytes in MS and non-MS brain tissue and on human oligodendrocytes in vitro. For this, we performed immunocytochemistry, Western blotting, TUNEL and FACS analysis for the presence of DR and apoptosis in sections of fresh frozen CNS tissue from… CONTINUE READING