Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells.

@article{Neuhaus2000MultipleSC,
  title={Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells.},
  author={Oliver Neuhaus and Cinthia Farina and A. Yassouridis and Heinz Wiendl and Florian Then Bergh and Tatjana Dose and Hartmut Wekerle and Reinhard Hohlfeld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 13},
  pages={7452-7}
}
Copolymer 1 (COP), a standardized mixture of synthetic polypeptides consisting of l-glutamic acid, l-lysine, l-alanine, and l-tyrosine, has beneficial effects in multiple sclerosis and experimental autoimmune encephalomyelitis. We selected a panel of 721 COP-reactive T cell lines (TCL) from the blood of COP-treated and untreated multiple sclerosis patients and from healthy donors by using the split-well cloning technique. All TCL selected with COP proliferated in response to COP but not to… CONTINUE READING

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