Multiple sclerosis: Repurposing dopaminergic drugs for MS — the evidence mounts

@article{Marino2016MultipleSR,
  title={Multiple sclerosis: Repurposing dopaminergic drugs for MS — the evidence mounts},
  author={Franca Marino and Marco Cosentino},
  journal={Nature Reviews Neurology},
  year={2016},
  volume={12},
  pages={191-192}
}
A new study has shown that both in patients with multiple sclerosis (MS) and in healthy controls, dopamine inhibits production of IL-17 and IFN-γ by peripheral blood mononuclear cells. The finding adds to previous evidence for the potential benefit of dopaminergic drugs in MS. 
Dopaminergic Receptor Targeting in Multiple Sclerosis: Is There Therapeutic Potential?
TLDR
The influence of dopamine receptor targeting on experimental autoimmune encephalomyelitis (EAE) and MS pathogenesis, as well as the therapeutic potential of dopaminergic drugs as add-on pathogenetic therapy of MS, are discussed.
Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions
TLDR
It is suggested that targeting dopaminergic receptors could be explored as a new kind of disease-modifying treatment of MS.
Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
TLDR
This is the first study reporting the beneficial effects of DAT inhibitor-based treatment in animals with induced autoimmune encephalomyelitis, and the observed results provide additional support to the model of DA-related neuroinflammation.
[Norepinephrine and intestinal microbiome in the early stages of demyelination: clinical-immunological parallels].
TLDR
A role of norepinephrine in the regulation of neuroimmune interactions in the early stages of the demyelination of patients with CIS, RIS and early MS is addressed.
Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells
TLDR
It is demonstrated that PZH had a therapeutic effect on RR-EAE mice, which was associated with the modulation effect on Th1 and Th17 cells, and could inhibit the phosphorylation of some key proteins in the STAT and NF-κB signaling pathways.
Dopaminergic stimulation leads B-cell infiltration into the central nervous system upon autoimmunity
TLDR
The findings demonstrate that DRD3 in B cells exerts a dual role in CNS-autoimmunity, favouring CNS-tropism of pro-inflammatory B cells with APC-function and promoting CNS-homing of B Cells with anti-inflammatory features.
...
1
2
3
...

References

SHOWING 1-10 OF 11 REFERENCES
Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?
Multiple sclerosis (MS) is an autoimmune disorder of the CNS characterized by inflammation, demyelination and axonal loss. Classical evidence in experimental allergic encephalomyelitis, the animal
Immunopathogenesis and immunotherapy of multiple sclerosis
TLDR
Current knowledge of the immunopathogenesis of MS and corresponding animal models of disease is reviewed, new immunointerventional treatment strategies based on changing pathogenetic concepts are discussed, and new immunotherapeutic agents developed and evaluated in clinical trials are discussed.
The Dopaminergic System in Autoimmune Diseases
TLDR
Dopaminergic analogs had beneficial therapeutic effects in animal models, and in patients with lupus or RA, and are proposed models that may underlie key roles of dopamine and its receptors in autoimmune diseases.
Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.
TLDR
Observations suggest an enrichment of both IL-17+CD4+ and CD8+ T cells in active MS lesions as well as an important role for IL- 17 in MS pathogenesis, with some remarkable differences from the experimental autoimmune encephalomyelitis model.
Nerve-driven immunity : neurotransmitters and neuropeptides in the immune system
TLDR
An attempt is made to evaluate the role of glutamate receptors in the immune system and the effects of neurotransmitters on immune cells, functions and disease in relation to CGRP.
Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop.
TLDR
It is shown that in human Tregs endogenous catecholamines subserve an autocrine/paracrine loop involving dopaminergic pathways and resulting in down-regulation of Treg function, which occurs without affecting the production of tumor necrosis factor-alpha or interferon-gamma.
The Physiology, Signaling, and Pharmacology of Dopamine Receptors
TLDR
D dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms are discussed.
...
1
2
...