MS Disease and Providing a Biologic Perspective and Reducing the Symptoms of the Disease with the Help of Stem Cells
The use of stem cells for treating patients with MS has been fruitful and can be used to treat MS, and complications of these cells are low in patients and provide an acceptable response.
Multiple sclerosis: Therapeutic applications of advancing drug delivery systems.
- Biology, MedicineBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease
- Biology, MedicineInternational journal of molecular sciences
A comparison of SC lesions in MS and TMEV-IDD focusing on spatial and temporal distribution of demyelination, inflammation, SC atrophy (SCA), and axonal degeneration/loss in major descending motor pathways indicates the suitability of TMEv- IDD as animal model also for the investigation of progressive SC patients in MS.
Identification of Altered Metabolic Pathways during Disease Progression in EAE Mice via Metabolomics and Lipidomics
Comparison between cerebrospinal fluid and serum levels of myelin-associated glycoprotein, total antioxidant capacity, and 8-hydroxy-2′-deoxyguanosine in patients with multiple sclerosis
- MedicineClinical Neurology and Neurosurgery
Multiple Sclerosis: Immunopathology and Treatment Update
- Biology, MedicineBrain sciences
Go back to the basics to understand the immunopathophysiology of MS to gain insights in the development of new improved drug treatments and present current disease-modifying therapies for the treatment of MS.
The role of vitamin D and P2X7R in multiple sclerosis
- Biology, PsychologyJournal of Neuroimmunology
ApoE4-positive multiple sclerosis patients are more likely to have cognitive impairment: a cross-sectional study
- Psychology, MedicineNeurological Sciences
MS ApoE4-positive patients are more likely to have at least one impaired cognitive test, but there is a need for more studies with larger sample sizes and based on MS-specific cognitive tests to confirm these findings.
High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
- BiologyFrontiers in Molecular Neuroscience
Recent studies that have employed high-resolution gene expression profiling technologies in the context of MS and their respective advantages and disadvantages are reviewed.
Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis
- Biology, MedicineClinical and translational science
Labeling myelin breakdown products is a useful method that can be used to quantify myelin turnover in patients with progressive MS and can therefore be used in proof‐of‐concept studies with remyelination therapies.
SHOWING 1-10 OF 129 REFERENCES
Natural history of multiple sclerosis
- Psychology, MedicineNeurologic clinics
Primary progressive MS may differ from relapsing‐remitting MS in MRI lesion frequency, immunogenetic profile, responsiveness to immunosuppressive treatment, and histology.
Current Concepts in Multiple Sclerosis: Autoimmunity Versus Oligodendrogliopathy
- Biology, MedicineClinical Reviews in Allergy & Immunology
New neuropathological evidence now argues against the autoimmune hypothesis and suggests that MS is a primary oligodendrogliopathy disease in which the inflammatory response may be a mere epiphenomenon.
Disease Biomarkers in Multiple Sclerosis
- BiologyMolecular Diagnosis & Therapy
Biomarkers that correlate with myelin loss, spinal cord disease, grey matter and subcortical demyelination need to be developed in order to accurately predict the disease course.
Multiple sclerosis: geoepidemiology, genetics and the environment.
- Medicine, BiologyAutoimmunity reviews
The differential diagnosis of multiple sclerosis: classification and clinical features of relapsing and progressive neurological syndromes
- Medicine, PsychologyNeurological Sciences
The key to the accurate diagnosis of MS is vigilance for atypical features, suggesting the possibility of an alternative diagnosis.
Multiple Sclerosis between Genetics and Infections: Human Endogenous Retroviruses in Monocytes and Macrophages
- BiologyFront. Immunol.
The association between HERVs and MS is well documented and a pathological role for MSRV in MS is plausible, and further studies are required to determine whether the presence of these HERVs is a cause or an effect of immune dysregulation in MS.
Microbial view of central nervous system autoimmunity
- Biology, MedicineFEBS letters
Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation
- Medicine, BiologyFront. Immunol.
The purpose of this review is to examine the evidence that supports a role for peripheral infection in modulating the natural history of multiple sclerosis and a few mechanisms by which infection may exacerbate symptoms of MS and other neurological diseases.