Multiple sclerosis: New insights and trends

@article{Koriem2016MultipleSN,
  title={Multiple sclerosis: New insights and trends},
  author={Khaled M. M. Koriem},
  journal={Asian pacific Journal of Tropical Biomedicine},
  year={2016},
  volume={6},
  pages={429-440}
}
  • K. Koriem
  • Published 1 May 2016
  • Biology, Medicine
  • Asian pacific Journal of Tropical Biomedicine
MS Disease and Providing a Biologic Perspective and Reducing the Symptoms of the Disease with the Help of Stem Cells
TLDR
The use of stem cells for treating patients with MS has been fruitful and can be used to treat MS, and complications of these cells are low in patients and provide an acceptable response.
Comparison of Reported Spinal Cord Lesions in Progressive Multiple Sclerosis with Theiler’s Murine Encephalomyelitis Virus Induced Demyelinating Disease
TLDR
A comparison of SC lesions in MS and TMEV-IDD focusing on spatial and temporal distribution of demyelination, inflammation, SC atrophy (SCA), and axonal degeneration/loss in major descending motor pathways indicates the suitability of TMEv- IDD as animal model also for the investigation of progressive SC patients in MS.
Multiple Sclerosis: Immunopathology and Treatment Update
TLDR
Go back to the basics to understand the immunopathophysiology of MS to gain insights in the development of new improved drug treatments and present current disease-modifying therapies for the treatment of MS.
ApoE4-positive multiple sclerosis patients are more likely to have cognitive impairment: a cross-sectional study
TLDR
MS ApoE4-positive patients are more likely to have at least one impaired cognitive test, but there is a need for more studies with larger sample sizes and based on MS-specific cognitive tests to confirm these findings.
High-Resolution Transcriptomic and Proteomic Profiling of Heterogeneity of Brain-Derived Microglia in Multiple Sclerosis
TLDR
Recent studies that have employed high-resolution gene expression profiling technologies in the context of MS and their respective advantages and disadvantages are reviewed.
Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis
TLDR
Labeling myelin breakdown products is a useful method that can be used to quantify myelin turnover in patients with progressive MS and can therefore be used in proof‐of‐concept studies with remyelination therapies.
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