Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts

  title={Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts},
  author={Devin R. Scannell and Kevin P. Byrne and Jonathan L. Gordon and Simon Wong and Kenneth H. Wolfe},
A whole-genome duplication occurred in a shared ancestor of the yeast species Saccharomyces cerevisiae, Saccharomyces castellii and Candida glabrata. Here we trace the subsequent losses of duplicated genes, and show that the pattern of loss differs among the three species at 20% of all loci. For example, several transcription factor genes, including STE12, TEC1, TUP1 and MCM1, are single-copy in S. cerevisiae but are retained in duplicate in S. castellii and C. glabrata. At many loci, different… 
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