Multiple roles of ubiquitination in the control of nucleotide excision repair.

@article{Nouspikel2011MultipleRO,
  title={Multiple roles of ubiquitination in the control of nucleotide excision repair.},
  author={Thierry P Nouspikel},
  journal={Mechanisms of ageing and development},
  year={2011},
  volume={132 8-9},
  pages={355-65}
}
Nucleotide excision repair (NER) is a remarkably versatile DNA repair system, essential for maintenance of genomic stability. Hereditary alterations in NER enzymes can result in increased cancer propensity, but also in developmental, neurodegenerative, and progeroid syndromes. NER can be operationally divided in three subtypes, which share many common steps: global genomic repair (GGR) operates on the whole genome level, transcription domain-associated repair (DAR) is a concentration of NER… CONTINUE READING