Multiple roles of serotonin in pain control mechanisms--implications of 5-HT₇ and other 5-HT receptor types.

@article{Viguier2013MultipleRO,
  title={Multiple roles of serotonin in pain control mechanisms--implications of 5-HT₇ and other 5-HT receptor types.},
  author={Florent Viguier and Beno{\^i}t Michot and Michel Hamon and Sylvie Bourgoin},
  journal={European journal of pharmacology},
  year={2013},
  volume={716 1-3},
  pages={8-16}
}
Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex modulatory roles in pain signaling mechanisms since the first reports, about forty years ago, on its essentially pro-nociceptive effects at the periphery and anti-nociceptive effects when injected directly at the spinal cord level. The discovery of multiple 5-HT receptor subtypes allowed possible explanations to this dual action at the periphery versus the central nervous system (CNS) since both excitatory and… CONTINUE READING