Multiple roles of eph receptors and ephrins in neural development

  title={Multiple roles of eph receptors and ephrins in neural development},
  author={David G. Wilkinson},
  journal={Nature Reviews Neuroscience},
  • D. Wilkinson
  • Published 1 March 2001
  • Biology
  • Nature Reviews Neuroscience
The control of cell movement during development is essential for forming and stabilizing the spatial organization of tissues and cell types. During initial steps of tissue patterning, distinct regional domains or cell types arise at appropriate locations, and the movement of cells is constrained in order to maintain spatial relationships during growth. In other situations, the guidance of migrating cells or neuronal growth cones to specific destinations underlies the establishment or… 
The role of the Eph-ephrin signalling system in the regulation of developmental patterning.
This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system.
EphA5 and EphA6: regulation of neuronal and spine morphology
Novel functions of these Eph receptors in the regulation of neuronal and spine structure in brain development and function are suggested.
Vascular patterning by Eph receptor tyrosine kinases and ephrins.
  • R. Adams
  • Biology
    Seminars in cell & developmental biology
  • 2002
This review highlights the large family of Eph receptor tyrosine kinases and their ligands, called ephrins, which, because of their versatile functions in many cell and tissue types and their molecular complexity, might well provide one example of a control system integrating blood vessel and tissue morphogenesis.
Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function.
This review summarizes the diverse biological roles of ephrins and Ephs in embryonic development, including patterning and morphogenetic processes of the nervous and vascular systems, and in the adult, such as synaptic plasticity.
Ephrins in reverse, park and drive.
Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation.
Axon guidance processes in the retinotectal and vomeronasal projection are controlled by Eph receptor tyrosine kinases and ephrins.
Recent findings derived from investigating the role of the EphA family during development of the retinotectal and vomeronasal projection are summarized, uncovering a role of ephrin-A molecules as axon guidance receptors.


Roles of Eph receptors and ephrins in neural crest pathfinding
This review discusses recent work that has implicated Eph receptors and their ephrin ligands in mediating repulsive interactions that restrict neural crest cell migration and relates these findings to the roles of these receptors and ligand in growth cone guidance and the segmental restriction of cell movement in the hindbrain.
The ephrins and Eph receptors in neural development.
The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps, and may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system.
In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins
Mosaic activation of Eph receptors leads to sorting of cells to boundaries in odd-numbered rhombomeres, whereas mosaic activation of ephrins results in sorting to boundaries of cell intermingling in even- numbered rhombomes.
Ephrin-dependent growth and pruning of hippocampal axons.
It is reported here that the ligands of the Eph family tyrosine kinase receptors may regulate both the initial outgrowth and the subsequent pruning of axons, and that the ephrins and their receptors may regulating topographic map formation by stimulating axonal arborization and by pruning mistargeted axons.
Eph receptors and ephrins: regulators of guidance and assembly.
The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis.
The findings demonstrate that EphB4 and B-class ephrins act as regulators of angiogenesis possibly by mediating repulsive guidance cues to migrating endothelial cells.
Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.
Subcellular localization of Nuk, as well as the presence of fibronectin type III and immunoglobulin-like adhesive domains on the extracellular region, suggest this receptor tyrosine kinase may function to regulate specific cell-cell interactions during early development of the murine nervous system.