Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.

@article{Deng2014MultipleRO,
  title={Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms.},
  author={Huai Deng},
  journal={Fly},
  year={2014},
  volume={8 1},
  pages={
          7-12
        }
}
Xenobiotic and oxidative responses protect cells from external and internal toxicities. Nrf2 and Keap1 are central factors that mediate these responses, and are closely related with many human diseases. In a recent study, we revealed novel developmental function and regulatory mechanism of Nrf2 and Keap1 by investigating their Drosophila homolog CncC and dKeap1. We found that CncC and dKeap1 control metamorphosis through regulations of ecdysone biosynthetic genes and ecdysone response genes in… CONTINUE READING
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