Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair.

  title={Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair.},
  author={Jennifer J. Rahn and Gerald M. Adair and Rodney S. Nairn},
  journal={Environmental and molecular mutagenesis},
  volume={51 6},
DNA interstrand crosslinks (ICLs) are among the most deleterious cytotoxic lesions encountered by cells, mainly due to the covalent linkage these lesions create between the two strands of DNA which effectively blocks replication and transcription. Although ICL repair in mammalian cells is not fully understood, processing of these lesions is thought to begin by "unhooking" at the site of the damaged base accompanied by the generation of a double strand break and ultimately repair through… CONTINUE READING

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