Multiple roles for the yeast SUB2/yUAP56 gene in splicing.

  title={Multiple roles for the yeast SUB2/yUAP56 gene in splicing.},
  author={Domenico Libri and No{\"e}l Graziani and Cyril Saguez and Jocelyne Boulay},
  journal={Genes & development},
  volume={15 1},
The UAP56 gene has been shown to be required for prespliceosome assembly in mammals. We report here the isolation of the Schizosaccharomyces pombe ortholog of this gene by heterologous complementation of a combined PRP40HA(3)/nam8Delta defect in budding yeast. The Saccharomyces cerevisiae ortholog, YDL084w/SUB2, is also able to suppress this defect. We show that SUB2 is involved in splicing in vivo as well as in vitro. Sub2 defective extracts form a stalled intermediate that contains U2snRNP… CONTINUE READING

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