Multiple roles for Src in a PDGF-stimulated cell.

  title={Multiple roles for Src in a PDGF-stimulated cell.},
  author={Kris A Demali and Stephen L Godwin and Stephen P. Soltoff and Andrius Kazlauskas},
  journal={Experimental cell research},
  volume={253 1},
The observation that platelet-derived growth factor (PDGF) increases the catalytic activity of Src family members (Src) suggests that they contribute to PDGF-dependent responses. The role of Src in PDGF-dependent cell cycle progression, phosphorylation of proteins, and chemotaxis has been tested by investigators using a variety of cell types and approaches, and it appears that the contribution of Src is highly variable. This idea is perhaps best illustrated by the finding that Src plays… CONTINUE READING

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