Multiple role of reactive oxygen species in the arterial wall.

  title={Multiple role of reactive oxygen species in the arterial wall.},
  author={Claudio Napoli and Filomena de Nigris and Wulf Palinski},
  journal={Journal of cellular biochemistry},
  volume={82 4},
Increased oxidative stress plays an important role in vascular dysfunction and atherogenesis. Both systemic factors, such as hypercholesterolemia and hyperglycemia, and local factors, such as activation of macrophages and T cells, may contribute to oxidative stress. Oxidation of lipids in lipoproteins and cell membranes leads to functionally important modifications of proteins that affect their recognition by cell surface receptors and protein-protein interactions within the cell, including DNA… CONTINUE READING
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