Multiple ribosomal RNA cleavage pathways in mammalian cells.

  title={Multiple ribosomal RNA cleavage pathways in mammalian cells.},
  author={Lewis H. Bowman and Bruce Rabin and David Schlessinger},
  journal={Nucleic acids research},
  volume={9 19},
The sequence content of mouse L cell pre-rRNA was examined by RNA gel transfer and blot hybridization. Nuclear RNAs were separated by agarose gel electrophoresis, transferred to diazo-paper, and hybridized to twelve different restriction fragments that are complementary to various sections of 45S pre-rRNA. An abundant new 34S pre-rRNA and less abundant new 37S, 26S and 17S pre-rRNAs were detected. The presence of these new pre-rRNAs suggests the existence of at least two new pre-rRNA cleavage… CONTINUE READING


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