Multiple resistance mechanisms in Chinese hamster cells resistant to 9-hydroxyellipticine.

  title={Multiple resistance mechanisms in Chinese hamster cells resistant to 9-hydroxyellipticine.},
  author={Annette Kragh Larsen and Alain G Jacquemin-Sablon},
  journal={Cancer research},
  volume={49 24 Pt 1},
We have previously shown that Chinese hamster lung cells resistant to 9-hydroxyellipticine, DC-3F/9-OH-E, display multiple phenotypical alterations including cross-resistance to a variety of drugs as well as loss of tumorigenicity. We now analyze a DC-3F/9-OH-E subline that has been maintained for a prolonged period of time in drug-free medium in order to clarify the relationships between the various phenotypic traits. The absence of selection resulted in a partial recovery of the ability to… CONTINUE READING


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