Multiple repressive mechanisms in the hippocampus during memory formation

@article{Cho2015MultipleRM,
  title={Multiple repressive mechanisms in the hippocampus during memory formation},
  author={Jun Hwi Cho and Nam-Kyung Yu and Jun-Hyeok Choi and Su-Eon Sim and Sukjae Joshua Kang and Chuljung Kwak and Seung-woo Lee and Ji-Il Kim and Dong Il Choi and V. Narry Kim and Bong-Kiun Kaang},
  journal={Science},
  year={2015},
  volume={350},
  pages={82-87}
}
Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale. We used ribosome profiling and RNA sequencing to quantify the translational status and transcript levels in the mouse hippocampus after contextual fear conditioning. We revealed three types of repressive regulations: translational suppression of ribosomal protein-coding genes in the… CONTINUE READING
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