Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection.

@article{Kerry1996MultipleRE,
  title={Multiple regulatory events influence human cytomegalovirus DNA polymerase (UL54) expression during viral infection.},
  author={Julie A. Kerry and Michelle Priddy and T Y Jervey and C P Kohler and Thomas L. Staley and Cynthia D. Vanson and Trevor Jones and A C Iskenderian and David G. Anders and Richard M. Stenberg},
  journal={Journal of virology},
  year={1996},
  volume={70 1},
  pages={
          373-82
        }
}
The human cytomegalovirus (HCMV) DNA polymerase gene (UL54; also called pol) is a prototypical early gene in that expression is mandatory for viral DNA replication. Recently, we have identified the major regulatory element in the UL54 promoter responsive to the major immediate early (MIE) proteins (UL122 and UL123) (J.A. Kerry, M.A. Priddy, and R. M. Stenberg, J. Virol. 68:4167-4176, 1994). Mutation of this element, inverted repeat sequence 1 (IR1), abrogates binding of cellular proteins to the… CONTINUE READING

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