Multiple regions contribute to membrane targeting of Rab GTPases.

  title={Multiple regions contribute to membrane targeting of Rab GTPases.},
  author={Bassam R Ali and Christina Wasmeier and Lynn Lamoreux and Molly Strom and Miguel C. Seabra},
  journal={Journal of cell science},
  volume={117 Pt 26},
Small GTPases of the Rab family are key regulators of membrane trafficking. Each Rab shows a characteristic subcellular distribution, and may serve as an important determinant of organelle identity. The molecular mechanisms responsible for targeting Rabs to specific intracellular compartments, however, remain poorly understood. The divergent C-terminal hypervariable region was postulated to contain Rab targeting information. We generated a series of hybrid Rab proteins by exchanging the… CONTINUE READING