Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.

@article{Kitteringham2009MultipleRM,
  title={Multiple reaction monitoring for quantitative biomarker analysis in proteomics and metabolomics.},
  author={Neil R. Kitteringham and Rosalind Jenkins and Catherine S. Lane and Victoria L Elliott and Brian Kevin Park},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 13},
  pages={1229-39}
}
The conventional pipeline for biomarker development involves a discovery phase, typically conducted by mass spectrometry (MS), followed by validation and clinical application, usually on an alternative platform, such as immunoassay. Whilst this approach is suitable for the development of single biomarkers, with the current drive towards larger panels of multiplexed biomarkers, the process becomes inefficient and costly. Consequently, the emphasis is now shifting towards performing full… CONTINUE READING
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