Multiple reaction monitoring as a method for identifying protein posttranslational modifications.

@article{Cox2005MultipleRM,
  title={Multiple reaction monitoring as a method for identifying protein posttranslational modifications.},
  author={David M. Cox and Fengquan Zhong and Mingjuan Du and Eva Duchoslav and Toshie Sakuma and John C. McDermott},
  journal={Journal of biomolecular techniques : JBT},
  year={2005},
  volume={16 2},
  pages={83-90}
}
The activity of many transcriptional regulators is significantly altered by posttranslational modifications of specific sites. For example, the activity of the muscle-restricted transcription factor family myocyte enhancer factor 2 (MEF2) is tightly controlled by phosphorylation. This modification is responsible for either an increase or a decrease in transcriptional activity, depending on the specific amino acid residues that are phosphorylated by signal-dependent kinases. Although mass… CONTINUE READING

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