Multiple quantitative trait loci Haseman–Elston regression using all markers on the entire genome

@article{Zhang2008MultipleQT,
  title={Multiple quantitative trait loci Haseman–Elston regression using all markers on the entire genome},
  author={Yuan-Ming Zhang and Hai-yan L{\"u} and Li-li Yao},
  journal={Theoretical and Applied Genetics},
  year={2008},
  volume={117},
  pages={683-690}
}
The Haseman–Elston (HE) regression, developed in the 1970s, remains in common use to detect genetic linkage between a quantitative trait and a genetic marker. Although the technique has been improved in a number of ways, it predicts a high rate of false positive quantitative trait locus (QTL) because it is based on a single-QTL model. We have extended the origin HE regression to multi-QTL HE (MQHE) regression, so that all markers across the entire genome can be exploited simultaneously. The… CONTINUE READING

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