Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.

@article{Chen2002MultiplePA,
  title={Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.},
  author={Yi-qing Chen and Yong-qing Zhou and L T Fu and Dong Wang and Ming-Hai Wang},
  journal={Carcinogenesis},
  year={2002},
  volume={23 11},
  pages={1811-9}
}
The receptor tyrosine kinase RON (recepteur d'origine nantais), a member of the MET proto-oncogene family, has been implicated in the pathogenesis of certain epithelial cancers including lung adenocarcinomas. To determine the oncogenic potential of RON, transgenic mice were generated using the surfactant protein C promoter to express human wild-type RON in the distal lung epithelial cells. The mice were born normal without morphological defects in the lung, however, multiple lung adenomas with… CONTINUE READING

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