Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.

@article{Schtze2016MultiplePI,
  title={Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.},
  author={Tonio Sch{\"u}tze and Alexander Carsten Ulrich and Luise Karin Apelt and Cindy L Will and Natascha Bartlick and Martin Seeger and Gert Weber and Reinhard L{\"u}hrmann and Ulrich Stelzl and Markus C Wahl},
  journal={RNA},
  year={2016},
  volume={22 2},
  pages={
          265-77
        }
}
Spliceosomal Prp38 proteins contain a conserved amino-terminal domain, but only higher eukaryotic orthologs also harbor a carboxy-terminal RS domain, a hallmark of splicing regulatory SR proteins. We show by crystal structure analysis that the amino-terminal domain of human Prp38 is organized around three pairs of antiparallel α-helices and lacks similarities to RNA-binding domains found in canonical SR proteins. Instead, yeast two-hybrid analyses suggest that the amino-terminal domain is a… CONTINUE READING

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