Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis.

@article{Perego1994MultiplePP,
  title={Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis.},
  author={Maristella Perego and C G Hanstein and Kevin M. Welsh and T Djavakhishvili and Philippe Glaser and James A. Hoch},
  journal={Cell},
  year={1994},
  volume={79 6},
  pages={1047-55}
}
The initiation of sporulation in B. subtilis is regulated by the Spo0A transcription factor, which is activated by phosphorylation to control developmental switching from the vegetative to the sporulation state. The level of phosphorylation of Spo0A is regulated by the phosphorelay, a signal transduction system based on the protein-histidine kinase-response regulator two-component paradigm. To initiate sporulation, the cell must recognize and interpret a large variety of environmental… CONTINUE READING
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