Multiple protein-DNA interactions over the yeast HSC82 heat shock gene promoter.

@article{Erkine1995MultiplePI,
  title={Multiple protein-DNA interactions over the yeast HSC82 heat shock gene promoter.},
  author={Alexander M. Erkine and Christopher C. Adams and Ming Gao and David S Gross},
  journal={Nucleic acids research},
  year={1995},
  volume={23 10},
  pages={1822-9}
}
We have utilized DNase I and micrococcal nuclease (MNase) to map the chromatin structure of the HSC82 heat shock gene of Saccharomyces cerevisiae. The gene is expressed at a high basal level which is enhanced 2-3-fold by thermal stress. A single, heat-shock invariant DNase I hypersensitive domain is found within the HSC82 chromosomal locus; it maps to the gene's 5' end and spans 250 bp of promoter sequence. DNase I genomic footprinting reveals that within this hypersensitive region are four… CONTINUE READING

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